This policy brief provides an accessible overview of the European Research Area (ERA) Policy Agenda 2025–2027 and its relevance for Marie Skłodowska-Curie Actions (MSCA) applicants, supervisors, and National Contact Points. It explains the main ERA priorities, including research careers, open science, research security, AI in science, and research assessment reform, while highlighting how these priorities can be reflected in MSCA proposals across the Excellence, Impact, and Implementation sections. The document also outlines the key changes introduced in the new ERA Policy Agenda compared to the 2022–2024 cycle and offers practical examples and resources to help applicants better align their projects with broader European research and innovation objectives.