The proposal results from close collaboration between the Commission, Member States, Horizon Europe Associated Countries, and European stakeholders within the ERA Forum. Like the first ERA Policy Agenda 2022-2024, it serves as a three-year roadmap to drive progress in areas such as open science and research assessment reform. Its goal is to transform the Pact for Research and Innovation’s priorities into concrete outcomes that enhance long-term cooperation across the EU. The agenda includes structural policies like open science and research careers, alongside targeted actions addressing challenges such as AI in science and research security. Expected results include a joint AI roadmap, strengthened cooperation on research security, and a European science-for-policy observatory.